V900931

Trichostatin A 

Vetec^™, reagent grade, from Streptomyces sp., ≥98%

• Synonym(s): Trichostatin A, TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
• Empirical Formula (Hill Notation): C₁₇H₂₂N₂O₃
• CAS Number: 58880-19-6
• Molecular Weight: 302.37
• MDL number: MFCD03848392
• UNSPSC Code: 12352200
• PubChem Substance ID: 329830233

Properties

• biological source: Streptomyces sp.
• grade: reagent grade
• product line: Vetec^™
• Assay: ≥98%
• storage temp.: −20°C
• SMILES string: C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
• InChI: 1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
• InChI key: RTKIYFITIVXBLE-QEQCGCAPSA-N

Description

Biochem/physiol Actions

Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.

Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3