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1218005

USP

Diphenhydramine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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200 MG
$868.00

$868.00

Estimated to ship on14 April 2025

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200 MG
$868.00

About This Item

Empirical Formula (Hill Notation):
C17H21NO · HCl
CAS Number:
147-24-0
Molecular Weight:
291.82
MDL number:
MFCD00012479
UNSPSC Code:
41116107
PubChem Substance ID:
329749650
NACRES:
NA.24

$868.00

Estimated to ship on14 April 2025

Request a Bulk Order

grade

pharmaceutical primary standard

API family

diphenhydramine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diphenhydramine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride Tablets
  • Dimenhydrinate
  • Dimenhydrinate Tablets
  • Diphenhydramine and Phenylephrine Hydrochlorides Tablets
  • Diphenhydramine and Pseudoephedrine Capsules
  • Diphenhydramine Hydrochloride
  • Diphenhydramine Hydrochloride and Ibuprofen Capsules

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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D2600000

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Y0000135

Diphenhydramine impurity A, European Pharmacopoeia (EP) Reference Standard

1218016

Diphenhydramine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1217909

Diphenhydramine citrate, United States Pharmacopeia (USP) Reference Standard

1424209

Methylbenzhydrol, United States Pharmacopeia (USP) Reference Standard

38682

Diphenhydramine N-oxide hydrochloride, pharmaceutical impurity standard

1051602

Benzhydrol, United States Pharmacopeia (USP) Reference Standard

1218050

Diphenhydramine N-oxide, United States Pharmacopeia (USP) Reference Standard

1218027

Diphenhydramine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1899

Diphenhydramine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1897

Diphenhydramine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

BP896

Diphenhydramine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR1898

Diphenhydramine N-Oxide Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1993

Diphenhydramine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2071

Benzhydrol, Pharmaceutical Secondary Standard; Certified Reference Material

BP1119

Diphenylmethanol, British Pharmacopoeia (BP) Reference Standard

PHR2268

Diphenhydramine Citrate, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The Cochrane database of systematic reviews, 12(12), CD007094-CD007094 (2014-12-24)
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Xenobiotica; the fate of foreign compounds in biological systems, 44(10), 893-901 (2014-03-22)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in
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In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR). Here, we have
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Jung Yeon Kim et al.
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The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
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