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N12249

Isofenphos

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C15H24NO4PS
CAS Number:
25311-71-1
Molecular Weight:
345.39
Beilstein:
2949615
MDL number:
MFCD00041805
UNSPSC Code:
41116107
PubChem Substance ID:
329818526

grade

analytical standard

form

liquid

packaging

ampule of 100 mg

manufacturer/tradename

Chem Service, Inc. PS-1003

SMILES string

CCOP(=S)(NC(C)C)Oc1ccccc1C(=O)OC(C)C

InChI

1S/C15H24NO4PS/c1-6-18-21(22,16-11(2)3)20-14-10-8-7-9-13(14)15(17)19-12(4)5/h7-12H,6H2,1-5H3,(H,16,22)

InChI key

HOQADATXFBOEGG-UHFFFAOYSA-N

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General description

Isofenphos is an organophosphorus pesticide, used for the control of larvae of Popillia japonica Newman, soil-dwelling pests of corn (Amaze), Delia antiqua (Onion flies), Chamaepsila rosae (carrot flies), wireworms, etc. Toxicologically, the pesticide acts by the inhibition of acetylcholinesterase activity.

Application

Isofenphos may be used as an analytical reference standard for the determination of the pesticide residue in meat samples, leeks, rice and human tissues by various chromatography techniques.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H410

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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A Garrido-Frenich et al.
Journal of chromatography. A, 1133(1-2), 315-321 (2006-09-05)
The assessment of the recovery factor with the analyte concentration in meat samples has been studied for the determination of organochlorine and organophosphorus pesticides in meat by gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS). For that purpose, recent IUPAC recommendations, which
James B Knaak et al.
Critical reviews in toxicology, 34(2), 143-207 (2004-04-29)
A search of the scientific literature was carried out for physiochemical and biological data [i.e., IC50, LD50, Kp (cm/h) for percutaneous absorption, skin/water and tissue/blood partition coefficients, inhibition ki values, and metabolic parameters such as Vmax and Km] on 31
R C Wester et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 19(4), 521-526 (1992-11-01)
Studies were done to determine the percutaneous absorption of isofenphos in human volunteers from whom informed consent had been obtained. In vivo absorption in man was 3.6 +/- 3.6% of applied dose for 24-hr exposure and 3.6 +/- 0.5% for
L G Boros et al.
Leukemia research, 25(10), 883-890 (2001-09-05)
The organophosphate pesticide, isofenphos, is associated with human myeloid leukemia. In this study we describe metabolic changes in K562 myeloid blast cells from exposure to varying concentrations of isofenphos using the stable [1,2-13C(2)]glucose isotope as the single tracer and biological
J B Knaak et al.
Toxicology and applied pharmacology, 120(1), 106-113 (1993-05-01)
The rate of metabolism of [14C]isofenphos (IFP) to isofenphos oxon (IFP-oxon), des N-isofenphos (d-N-IFP), and des N-isofenphos oxon (d-N-IFP-oxon) by rat, guinea pig, monkey, dog, and human liver microsomal P-450 enzymes was studied to obtain Vmax and Km values for
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