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1,1,1,3,3,3-Hexafluoro-2-propanol

1,1,1,3,3,3-Hexafluoro-2-propanol
1 of 1 reviewers received a sample product or took part in a promotion

for LC-MS LiChropur

Synonym(s):

HFP, Hexafluoroisopropanol

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About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
Molecular Weight:
168.04
Beilstein:
1841007
MDL number:
UNSPSC Code:
12352104
NACRES:
NA.21
form:
liquid
Assay:
≥99.8% (GC)
Pricing and availability is not currently available.

Assay

≥99.8% (GC)

form

liquid

quality

for LC-MS LiChropur

impurities

≤0.02% water

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 ppm
Ca: ≤0.5 ppm
Cu: ≤0.02 ppm
Fe: ≤0.1 ppm
K: ≤2 ppm
Mg: ≤0.1 ppm
Na: ≤10 ppm

suitability

passes test for LC-MS (ESI/APCI pos. < 10 ppb)

SMILES string

OC(C(F)(F)F)C(F)(F)F

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

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General description

1,1,1,3,3,3-Hexafluoro-2-propanol(HFIP) is a thermally stable, highly polar, UV-transparent solvent that is misciblewith water and many polar organic solvents. It is used as a mobile phaseadditive in liquid chromatography-mass spectrometry (LC-MS) method to improveseparation and detection.[1][2]

Application

1,1,1,3,3,3-Hexafluoro-2-propanol can be used as a:
  • Buffer additive for LC-ESI-MS to separate acidic and basic compounds.[3]
  • Eluent additive in the UHPLC-MS/MS method to improve the chromatographic separation of basic and zwitterionic compounds.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2 Oral

Target Organs

Central nervous system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

No data available

Flash Point(C)

No data available


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1, 1, 1, 3, 3, 3-Hexafluoro-2-propanol
Phillips AJ and Roach JJ
e-EROS Encyclopedia of Reagents for Organic Synthesis, 1-9 (2001)
Retention mechanisms of acidic and basic analytes on the Pentafluorophenyl stationary phase using fluorinated eluent additives
Lossmann K, et al.
Journal of Chromatography A, 1666, 462850-462850 (2022)
Fluoroalcohols as novel buffer components for basic buffer solutions for liquid chromatography electrospray ionization mass spectrometry: retention mechanisms
Kipper K, et al.
Journal of Chromatography A, 1218(45), 8175-8180 (2011)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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