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WH0006741M1

Sigma-Aldrich

Monoclonal Anti-SSB antibody produced in mouse

clone 1D6-H5, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Sjogren syndrome antigen B (autoantigen La)

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100 μG
$933.00

$933.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
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100 μG
$933.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$933.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1D6-H5, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC001289

UniProt accession no.

P05455

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SSB(6741)

Related Categories

General description

The Sjogren syndrome antigen B (SSB) gene with 11 exons contains two alternative promoters 1 (P1) and 1′ (P1′) coding for SSB protein. The gene is mapped to human chromosome 2q31.1. The gene coded for a RNA-binding protein that is ubiquitously expressed.

Immunogen

SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Biochem/physiol Actions

Sjogren syndrome antigen B (SSB) plays a vital role in various stages of the RNA metabolism such as RNA polymerase III protection from exonuclease digestion, processing of specific cellular and viral RNA precursors, serving as an RNA chaperone, affecting telomere homeostasis and stimulating microRNA expression. It promotes proliferation, migration and invasion of cancer cells in vitro . In addition, it also enhances tumor growth in vivo. Overexpression of the gene has been observed in various types of cancers.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
06202-S5
05320-S5

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The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.
Heise T, et al.
Oncotarget, 7(20), 29664-29664 (2016)
Defective DNA methylation in salivary gland epithelial acini from patients with Sjogren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.
Konsta O D, et al.
Journal of Autoimmunity, 68, 30-38 (2016)

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