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SML3718

Sigma-Aldrich

SIAIS630121

≥98% (HPLC)

Synonym(s):

(E)-N-(4-(1-(4-(4-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)benzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide

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About This Item

Empirical Formula (Hill Notation):
C49H59N7O5
Molecular Weight:
826.04
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C(/C=C/C1=CN=CC=C1)NCCCCC2CCN(CC2)C(C3=CC=C(C=C3)N4CCN(CC4)CCCCCCC#CC5=CC=CC6=C5CN(C6=O)C7C(NC(CC7)=O)=O)=O

Biochem/physiol Actions

SIAIS630121 is an orally available, cell penetrant, potent and highly selective proteolysis-targeting chimera (PROTAC) that induces NAMPT (nicotinamide phosphoribosyltransferase) degradation in several cancer cells lines (SW620, HT29, and HCT116). It contains NAMPT inhibitor FK866 linked to cereblon (CRBN) ligand lenalidomide. SIAIS630121 exhibits rapid and potent degradation of iNAMPT and eNAMPT.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
Cell Chemical Biology, 29(11), 1616-1629 (2022)

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