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SML0635

Sigma-Aldrich

AZD6765 dihydrochloride

≥97% (HPLC)

Synonym(s):

(αS)-α-Phenyl-2-pyridineethanamine dihydrochloride, AR-R 15896 dihydrochloride, FPL 15896 dihydrochloride, Lanicemine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H14N2 · 2HCl
CAS Number:
153322-06-6
Molecular Weight:
271.19
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

powder

optical activity

[α]/D +77 to +90°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1

InChI key

KHJHFYAGQZYCLC-GXKRWWSZSA-N

Application

AZD6765 dihydrochloride has been used as an antidepressant to improve behavior and metabolic measures in chronic unpredictable mild stress (CUMS).

Biochem/physiol Actions

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC50 value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Pravin Kumar Mishra et al.
Neurochemistry international, 137, 104750-104750 (2020-05-04)
Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. Further, the

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