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SML0577

Sigma-Aldrich

Cucurbitacin E

≥95% (HPLC)

Synonym(s):

α-Elaterin, α-Elaterine

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5 MG
$306.00

$306.00

Estimated to ship on13 April 2025

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5 MG
$306.00

About This Item

Empirical Formula (Hill Notation):
C32H44O8
CAS Number:
18444-66-1
Molecular Weight:
556.69
UNSPSC Code:
12352200
NACRES:
NA.77

$306.00

Estimated to ship on13 April 2025

Request a Bulk Order

Quality Level

100

Assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -60 to -75°, c = 0.7 (CDCl3)

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

InChI

1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI key

NDYMQXYDSVBNLL-MUYMLXPFSA-N

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Application

Cucurbitacin E has been used as a cofilin inhibitor.[1] It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.[2]

Biochem/physiol Actions

Cucurbitacin E is a potent inhibitor of actin depolymerization.
Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000382448
0000382448
0000224384
0000224384
0000112898

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Pei-Lin Wu et al.
Chemical & pharmaceutical bulletin, 52(3), 345-349 (2004-03-03)
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray
Jing Qiao et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(5), 461-469 (2013-01-31)
Cucurbitacin E (CuE), a triterpenoid compound isolated from Cucurbitaceae plants, possesses a wide range of biological activities including anti-inflammatory properties. The present study aimed to investigate the anti-inflammatory effect of CuE and the underlying mechanism of action. The anti-inflammatory effect
Manali Dimri et al.
Development (Cambridge, England), 144(14), 2595-2605 (2017-07-20)
The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely established is not clear. We designed a new computer-based algorithm that quantitatively computes the structural differences of the
Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish
Dimri M, et al.
Development, 144(14), 2595-2605 (2017)
Chao-Ming Hung et al.
International journal of molecular sciences, 14(8), 17147-17156 (2013-08-24)
Human oral squamous cell carcinoma (OSCC) is a common form of malignant cancer, for which radiotherapy or chemotherapy are the main treatment methods. Cucurbitacin E (CuE) is a natural compound previously shown to be an antifeedant as well as a
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