SML0099

Fluocinonide

≥98% (HPLC)

• Synonym(s): (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, Lonide
• Empirical Formula (Hill Notation): C₂₆H₃₂F₂O₇
• CAS Number: 356-12-7
• Molecular Weight: 494.52
• EC Number: 206-597-6
• MDL number: MFCD00079302
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825157
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +75 to +90°, c = 1 in dichloromethane
• color: white to tan
• solubility: DMSO: ≥19 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C
• InChI: 1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
• InChI key: WJOHZNCJWYWUJD-IUGZLZTKSA-N
• Gene Information: human ... NR3C1(2908)

Description

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide has been used to study its effect on T-cell proliferation.

Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300,H361
• Precautionary Statements: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable