SAB4504424

Anti-phospho-HDAC8 (pSer³⁹) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 41 kDa
• species reactivity: rat, human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q9BY41
• UniProt accession no.: Q9BY41
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer39)
• Gene Information: human ... HDAC8(55869)

Description

General description

HDAC8 (histone deacetylase 8) is a class I enzyme, that has 377 residues and it lies between class I and class II HDACs. This gene is located on X chromosome. It consists of a single α/β domain, in which eight parallely stranded β sheets are sandwiched between 13 α helices.

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC8 around the phosphorylation site of Ser39.

Immunogen Range: 5-54

Biochem/physiol Actions

HDAC8 (histone deacetylase 8), with the help of PKA (cyclic AMP dependent protein kinase A), plays a major role in confirming the acetylation state of histones. This protein may also play an important role in acute myeloid leukemia (AML). Suppression of HDAC8 by RNA interference stops the growth of lung, colon, and cervical cancer cell lines.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable