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SAB2500308

Sigma-Aldrich

Anti-DGAT2 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-DKFZp686A15125, Anti-Diacylglycerol O-acyltransferase homolog 2, Anti-GS1999full, Anti-HMFN1045

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

canine, human, rat, mouse

technique(s)

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable

UniProt accession no.

Q96PD7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DGAT2(84649)

General description

Diacylglycerol O-acyltransferase 2 (DGAT2) possesses one or two transmembrane domains and the amino- and carboxyl-terminal regions face the cytosol. The gene encoding it is localized on human chromosome 11q13.5 and has eight exons.

Immunogen

Peptide with sequence C-KLEHPTQQDIDLYH from the internal region (near the C Terminus) of the protein sequence according to NP_115953.2.

Biochem/physiol Actions

Diacylglycerol O-acyltransferase 2 (DGAT2) is involved in the final step of triacylglycerol biosynthesis. It esterifies diacylglycerol to triacylglycerol. Overexpression of the protein has been associated with hepatic steatosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients.
Hu M
Journal of Lipid Research (2012)
Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene.
Nurminen R
Genes Chromosomes Cancer (2016)
Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes.
Li C
Arteriosclerosis, Thrombosis, and Vascular Biology (2015)
Justin Chun et al.
Journal of the American Society of Nephrology : JASN, 33(5), 889-907 (2022-03-03)
Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry are major contributors to the large racial disparity in rates of human kidney disease. We previously demonstrated that recruitment of APOL1 risk variants G1

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