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S8689

Sigma-Aldrich

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

Synonym(s):

SuperFas Ligand™

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About This Item

MDL number:
MFCD01092558
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

human

Quality Level

200

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-GE)

form

lyophilized powder

mol wt

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

technique(s)

ligand binding assay: suitable

UniProt accession no.

P48023

storage temp.

−20°C

Gene Information

human ... FASLG(356)

Application

ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.

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