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S1136

Sigma-Aldrich

[Nle11]-Substance P

≥97% (HPLC)

Synonym(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

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About This Item

Empirical Formula (Hill Notation):
C64H100N18O13
CAS Number:
57462-42-7
Molecular Weight:
1329.59
MDL number:
MFCD00076785
UNSPSC Code:
12352200
PubChem Substance ID:
24899461

Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CCCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(N)=O

InChI

1S/C64H100N18O13/c1-4-5-22-42(54(69)86)75-58(90)46(34-38(2)3)74-53(85)37-73-55(87)47(35-39-17-8-6-9-18-39)79-59(91)48(36-40-19-10-7-11-20-40)80-57(89)43(26-28-51(67)83)76-56(88)44(27-29-52(68)84)77-60(92)50-25-16-33-82(50)63(95)45(23-12-13-30-65)78-61(93)49-24-15-32-81(49)62(94)41(66)21-14-31-72-64(70)71/h6-11,17-20,38,41-50H,4-5,12-16,21-37,65-66H2,1-3H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,87)(H,74,85)(H,75,90)(H,76,88)(H,77,92)(H,78,93)(H,79,91)(H,80,89)(H4,70,71,72)

InChI key

ZEPTUBCWHRSMIP-UHFFFAOYSA-N

Biochem/physiol Actions

Substance P analog that avoids methionine oxidation problems

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Escher et al.
Journal of medicinal chemistry, 25(4), 470-475 (1982-04-01)
Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-acting analogues of this peptide hormone are known to date. In order to reach these goals, analogues of
R Landgraf et al.
Die Pharmazie, 38(2), 108-110 (1983-02-01)
The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after intracarotid injection of [3H] Nle11-SP or [14C] inulin
T N Akopyan et al.
Acta biologica et medica Germanica, 40(6), 779-784 (1981-01-01)
An ion exchange batchwise procedure was developed for the estimation of substance P degradation by rat brain fractions using 3H[Nle11]substance P as tracer. With this very sensitive and rapid method an especially high degradative activity was found among others in
R E Chipkin et al.
Archives internationales de pharmacodynamie et de therapie, 240(2), 193-202 (1979-08-01)
Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP(4--11) greater than SP = [Tyr7]-SP = [Eth11]-SP = [Nle11]-SP

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