R2027
Ral B human
recombinant, expressed in E. coli, buffered aqueous glycerol solution
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About This Item
recombinant
expressed in E. coli
Quality Level
form
buffered aqueous glycerol solution
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... RALB(5899)
Application
Can be used as a control in immunoblotting and in protein binding assays.
Biochem/physiol Actions
Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.
Ral B has been implicated in invasion and metastasis of human cancer cells. Reports have shown that depletion of Ral B by siRNA results in significantly reduced migration rates of tumor cells, while constitutively active Ral B promoted migration.
Other Notes
GST-tagged Ras-like fusion protein
Physical form
Supplied as a solution in 50 mM Tris, pH 7.5, containing 150 mM sodium chloride, 10 mM magnesium chloride, 1 mM DTT, and 10% glycerol.
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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Gary Oxford et al.
Cancer research, 65(16), 7111-7120 (2005-08-17)
The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of
Y Takai et al.
Physiological reviews, 81(1), 153-208 (2001-01-12)
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
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