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P4374

Sigma-Aldrich

Phthalocyanine tetrasulfonate hydrate

solid

Synonym(s):

29H,29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonic acid, PcTS, Phthalocyanine tetrasulfonic acid, Tetrasulfophthalocyanine

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About This Item

Empirical Formula (Hill Notation):
C32H18N8O12S4 · xH2O
CAS Number:
1173097-70-5
Molecular Weight:
834.79 (anhydrous basis)
MDL number:
MFCD08276972
UNSPSC Code:
12352200
PubChem Substance ID:
24724578

form

solid

Quality Level

100

storage condition

protect from light

color

dark blue

storage temp.

2-8°C

SMILES string

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

InChI key

QNPPZKALMXYKPI-UHFFFAOYSA-N

Application

Phthalocyanine tetrasulfonate hydrate has been used as a tau aggregation inhibitor (TAI) to study its effects on Tau secretion in neuroblastoma cells. It has also been used as an anionic phthalocyanine to study its effects on telomere G-quadruplex stabilization.

Biochem/physiol Actions

Inhibitor of protein aggregation, including α-synuclein, and the formation of protease-resistant prion protein.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Suzette A Priola et al.
The Journal of infectious diseases, 188(5), 699-705 (2003-08-23)
The transmissible spongiform encephalopathy (TSE) diseases are rare, neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans. There are no effective treatments available for clinical use in humans. We now demonstrate that, in 2
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