P105

(±)-PPHT hydrochloride

≥98% (HPLC), solid

• Synonym(s): (±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434
• Empirical Formula (Hill Notation): C₂₁H₂₇NO · HCl
• CAS Number: 71787-90-1
• Molecular Weight: 345.91
• MDL number: MFCD00055157
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277925

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: ≥10 mg/mL; H₂O: ≥2 mg/mL
• SMILES string: Cl[H].CCCN(CCc1ccccc1)C2CCc3c(O)cccc3C2
• InChI: 1S/C21H27NO.ClH/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23;/h3-10,19,23H,2,11-16H2,1H3;1H
• InChI key: XWLCIDLCEZAOEY-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Description

Biochem/physiol Actions

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Potent D₂ dopamine receptor agonist.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves