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M9318

Sigma-Aldrich

Anti-Melanocortin 4 Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-MC4R

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About This Item

MDL number:
MFCD02263636
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunocytochemistry: 4 μg/mL using human brain, caudate
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human brain, caudate

UniProt accession no.

P32245

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MC4R(4160)
mouse ... Mc4r(17202)
rat ... Mc4r(25635)

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human melanocortin 4 receptor. The immunizing peptide has 94% homology with the rat and mouse gene.

Biochem/physiol Actions

Melanocortin 4 receptor (MC4R) is an important regulator of food intake and body weight in mammals. It also regulates energy homeostasis in response to neuropeptides. Polymorphisms in MC4R gene or haploinsufficiency results in early onset obesity in humans also termed melanocortin obesity syndrome.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R A H Adan et al.
British journal of pharmacology, 149(7), 815-827 (2006-10-18)
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by
Andrew A Butler
Peptides, 27(2), 281-290 (2006-01-26)
The melanocortins, a family of peptides produced from the post-translational processing of pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of function mutations of genes encoding POMC, or of either of two melanocortin receptors expressed in the central nervous
Brandon L Panaro et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7050-7055 (2013-04-10)
Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin obesity syndrome, the most common monogenic cause of severe early onset obesity in humans. The syndrome, which produces measurable hyperphagia, has focused attention on the role of MC4R in feeding behavior

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