M2295
Myelin Basic Protein from guinea pig brain
≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain
Synonym(s):
MBP
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About This Item
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biological source
guinea pig brain
Assay
≥80% (SDS-PAGE)
form
lyophilized powder
technique(s)
cell based assay: suitable
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Gene Information
guinea pig ... MBP(100731253)
General description
Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.
Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system). It is an auto-immunogen.
Application
Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay
Biochem/physiol Actions
Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.
Quality
May contain traces of urea-glycine buffer salts.
Principle
Used as a kinase substrate.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Pedersen DS, et al.
Histochemistry and Cell Biology, 138(5), 787-802 (2012)
Sequence of guinea pig myelin basic protein.
Deibler GE
Journal of Neurochemistry, 43(1), 100-105 (1984)
J A Last et al.
Toxicology, 39(3), 247-257 (1986-06-01)
A synergistic interaction, as defined by biochemical and morphological criteria, between ozone (or NO2) and respirable aerosols of ammonium sulfate or sulfuric acid has been described previously. Experiments in the present paper show that it is the acidity, not the
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