L5408
LY-171,883
≥98% (TLC)
Synonym(s):
5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole, Tomelukast
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About This Item
Empirical Formula (Hill Notation):
C16H22N4O3
CAS Number:
Molecular Weight:
318.37
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
SMILES string
CCCc1c(O)c(ccc1OCCCCc2nnn[nH]2)C(C)=O
InChI
1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChI key
MWYHLEQJTQJHSS-UHFFFAOYSA-N
Biochem/physiol Actions
Selective leukotriene D4 (LTD4) receptor antagonist; PPARα and PPARγ agonist.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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J M Peters et al.
Molecular pharmacology, 50(1), 67-74 (1996-07-01)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) mediates the effects of foreign chemical peroxisome proliferators on liver and kidney, including the induction of peroxisomal, mitochondrial, and microsomal enzymes involved in beta-oxidation of fatty acids. However, the role of this receptor in
Kirsten Scholz-Pedretti et al.
Journal of the American Society of Nephrology : JASN, 13(3), 611-620 (2002-02-22)
Natural activators of peroxisome proliferator-activated receptors (PPAR) are lipid metabolites, including those produced by phospholipases A(2) (PLA(2)). In glomerular mesangial cells, the secreted group IIA PLA(2) (sPLA(2)-IIA), which is thought to be a crucial factor in pathologic processes in the
Common structural requirements for peroxisome proliferation by tetrazole and carboxylic acid-containing compounds.
P I Eacho et al.
Annals of the New York Academy of Sciences, 804, 387-402 (1996-12-27)
N L Anderson et al.
Toxicology and applied pharmacology, 137(1), 75-89 (1996-03-01)
We have investigated the effects of five peroxisome proliferators (PPs : clofibric acid, DEHP, WY14,643, nafenopin, and LY171883) on the abundances of a large number of proteins in the livers of treated mice at 5- and 35-day time points. LY171883
Ingalill Avis et al.
Cancer research, 65(10), 4181-4190 (2005-05-19)
Arachidonic acid (AA) metabolizing enzymes and peroxisome proliferator-activated receptors (PPARs) have been shown to regulate the growth of epithelial cells. We have previously reported that exposure to the 5-lipoxygenase activating protein-directed inhibitor MK886 but not the cyclooxygenase inhibitor, indomethacin, reduced
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