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H9006

Sigma-Aldrich

7-(β-Hydroxyethyl)theophylline

solid

Synonym(s):

1,3-Dimethyl-7-(2-hydroxyethyl)xanthine

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About This Item

Empirical Formula (Hill Notation):
C9H12N4O3
CAS Number:
519-37-9
Molecular Weight:
224.22
EC Number:
208-269-8
MDL number:
MFCD00055055
UNSPSC Code:
41106305
PubChem Substance ID:
24895836
NACRES:
NA.77

form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for several days at 4°C.)
ethanol: moderately soluble (Solutions may be stored for several days at 4°C.)

SMILES string

CN1C(=O)N(C)c2ncn(CCO)c2C1=O

InChI

1S/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3

InChI key

NWPRCRWQMGIBOT-UHFFFAOYSA-N

Gene Information

human ... ADORA2B(136)

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Application

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCD7594
SLBS9885
SLBQ7319V
SLBJ2159V
079K1318V

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Jainendra Kumar Jain et al.
Pakistan journal of pharmaceutical sciences, 21(2), 151-158 (2008-04-09)
The RP-HPLC (reverse phase high performance liquid chromatography) method was developed and validated for simultaneous determination of Multi drug components i.e., Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride in a liquid dosage form. Chromatographic separation of the four drugs was performed
S Gupta et al.
The Indian journal of chest diseases & allied sciences, 33(1), 1-8 (1991-01-01)
Pharmacokinetics of a sustained release (SR) and conventional formulations of theophylline plus hydroxyethyltheophylline was compared with tablet aminophylline. Time concentration curve of serum theophylline with the three formulations after single and multiple dosage schedules revealed significantly retarded absorption with the
Alessandro Lentini et al.
Melanoma research, 22(2), 133-139 (2012-02-02)
Differentiation-based therapeutics are an underutilized but potentially a significant option for cancer treatment. The effect of methylxanthines on melanoma cell differentiation has been well documented. We report the in-vitro and in-vivo anticancer potential of a theophylline analogue, 7-(2-hydroxyethyl)theophylline (HET), on
[The mechanisms of action of etophylline-clofibrate in hyperlipidemia].
I Păduraru et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 97(1), 445-449 (1993-01-01)
H N Dave et al.
Analytica chimica acta, 597(1), 113-120 (2007-07-31)
Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of salbutamol sulphate (SS), bromhexine hydrochloride (BH) and etofylline (ET) in pure and commercial formulations without any prior separation or purification. They were first
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