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H8653

Sigma-Aldrich

(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

Synonym(s):

(±)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
159795-63-8
Molecular Weight:
328.29
MDL number:
MFCD00153809
UNSPSC Code:
12352200
PubChem Substance ID:
24277938
NACRES:
NA.32

solubility

H2O: >15 mg/mL

Quality Level

200

storage temp.

2-8°C

SMILES string

Br.CCCN(CCC)C1CCc2ccc(O)cc2C1

InChI

1S/C16H25NO.BrH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H

InChI key

ODNDMTWHRYECKX-UHFFFAOYSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide is a selective D3 dopamine receptor agonist (Kd <1nM); has much weaker affinity for other dopamine receptor subtypes.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Maj et al.
European journal of pharmacology, 351(1), 31-37 (1998-08-11)
Previous studies have indicated that antidepressant drugs displaying different pharmacological profiles, administered repeatedly, increase the locomotor hyperactivity induced by various dopaminomimetics, among others by quinpirole. As this drug, according to a recent study, shows high affinity not only for dopamine
Zofia Rogóz et al.
Polish journal of pharmacology, 55(3), 449-454 (2003-09-25)
The aim of the present study was to examine a potential anxiolytic-like action of (+)-7-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (7-OH-DPAT), a preferential dopamine D(3) receptor agonist, and (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide (BP 897), partial dopamine D(3) receptor agonist. Diazepam was used as a reference compound. The
S B Caine et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 353-360 (1999-09-22)
The reinforcing effects of D(1-like) and D(2-like) agonists, and their capacity to modify cocaine self-administration, were compared in rats with extensive cocaine self-administration experience. Cocaine (0.01-1.0 mg i.v.) dose-dependently maintained responding under a fixed ratio (FR) 5 schedule of reinforcement
Michael D Staudt et al.
The journal of sexual medicine, 9(9), 2256-2265 (2011-12-23)
A population of lumbar spinothalamic cells (LSt cells) has been demonstrated to play a pivotal role in ejaculatory behavior and comprise a critical component of the spinal ejaculation generator. LSt cells are hypothesized to regulate ejaculation via their projections to
F N Dastur et al.
European journal of pharmacology, 382(2), 53-67 (1999-10-21)
The dopamine D(1) receptor agonist, R(+)-6-chloro-7, 8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF 81297), the dopamine D(2)/D(3) receptor agonist, trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo[3, 4-g]quinoline hydrochloride (quinpirole), and the dopamine D(3) receptor agonist, (+/-)-7-hydroxy-dipropylaminotetralin hydrobromide (7-OH-DPAT) all reduced the frequency of isolation-induced infant rat ultrasonic vocalizations and lowered
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