F105

Forskolin

• Synonym(s): 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin
• Empirical Formula (Hill Notation): C₂₂H₃₄O₇
• CAS Number: 66575-29-9
• Molecular Weight: 410.50
• Beilstein: 1692716
• EC Number: 266-410-9
• MDL number: MFCD00082317
• UNSPSC Code: 12352200

Properties

• storage temp.: −20°C
• SMILES string: CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C
• InChI: 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
• InChI key: OHCQJHSOBUTRHG-KGGHGJDLSA-N

Description

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H312
• Precautionary Statements: P280 - P302 + P352 + P312 - P362 + P364 - P501
• Hazard Classifications: Acute Tox. 4 Dermal
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves