D144
DALDA
>96%, solid
Synonym(s):
[D-Arg2, Lys4]-Dermorphin-(1-4)-amide
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About This Item
Empirical Formula (Hill Notation):
C30H44N8O6
CAS Number:
Molecular Weight:
612.72
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
>96%
form
solid
color
white
storage temp.
−20°C
SMILES string
NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O
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Amino Acid Sequence
Tyr-D-Arg-Phe-Lys-NH2
Biochem/physiol Actions
Highly selective μ opioid receptor agonist.
Storage Class Code
8B - Non-combustible corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Claire L Neilan et al.
The Journal of pharmacology and experimental therapeutics, 306(2), 430-436 (2003-03-29)
The dermorphin-derived peptide [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt, 2',6'-dimethyltyrosine) labels mu-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt1]DALDA displayed a mechanism of action distinct from that of morphine, as evidenced by its insensitivity to antisense
D Philippe et al.
Gut, 55(6), 815-823 (2005-11-22)
Recent studies with mu opioid receptor (MOR) deficient mice support a physiological anti-inflammatory effect of MOR at the colon interface. To better understand the potential pharmacological effect of certain opiates in inflammatory bowel diseases (IBD), we (1) evaluated the regulation
Irena Berezowska et al.
Acta biochimica Polonica, 51(1), 107-113 (2004-04-20)
Dansylated analogues of the potent and selective micro opioid peptide agonist [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2',6'-dimethyltyrosine) were prepared either by substitution of N(beta)-dansyl-alpha,beta-diaminopropionic acid or N(epsilon)-dansyllysine for Lys(4), or by attachment of a dansyl group to the C-terminal carboxamide function
Synthesis and pharmacological evaluation of highly potent [Dmt1]DALDA analogs.
P Anantha Reddy et al.
Advances in experimental medicine and biology, 611, 473-474 (2009-04-30)
P W Schiller et al.
The journal of peptide research : official journal of the American Peptide Society, 65(6), 556-563 (2005-05-12)
The dermorphin-derived tetrapeptide H-Dmt-d-Arg-Phe-Lys-NH(2) (Dmt = 2',6'-dimethyltyrosine) ([Dmt(1)]DALDA) is a highly potent and selective mu-opioid agonist capable of crossing the blood-brain barrier and producing a potent, centrally mediated analgesic effect when given systemically. For the purpose of biodistribution studies by
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