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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Synonym(s):

DCMB, LY-78335

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About This Item

Empirical Formula (Hill Notation):
C8H9Cl2N · HCl
CAS Number:
39226-94-3
Molecular Weight:
226.53
MDL number:
MFCD00055225
UNSPSC Code:
12352202
PubChem Substance ID:
24278157

form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES string

Cl[H].CC(N)c1cccc(Cl)c1Cl

Gene Information

human ... PNMT(5409)

Biochem/physiol Actions

PNMT inhibitor.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Lowering of epinephrine concentration in rat brain by 2,3-dichloro-alpha-methyl-benzylamine, an inhibitor of norepinephrine N-methyltransferase.
R W Fuller et al.
Biochemical pharmacology, 26(21), 2087-2090 (1977-11-01)
N Y Liang et al.
Research communications in chemical pathology and pharmacology, 37(3), 445-452 (1982-09-01)
Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats. In the drug-treated animals, the time course for reduction of body temperature was better correlated
B A Adler et al.
Endocrinology, 113(4), 1431-1438 (1983-10-01)
Results from previous investigations have suggested an important role for central epinephrine (EPI) systems in mediating the stimulatory effects of ovarian hormones on LH release in ovariectomized female rats. The purpose of these experiments was 1) to test whether selective
Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
R W Fuller et al.
Biochemical pharmacology, 30(11), 1345-1352 (1981-06-01)
I N Mefford et al.
Alcoholism, clinical and experimental research, 14(1), 53-57 (1990-02-01)
The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N-methyltransferase (PNMT), LY134046 and LY78335, proved to be potent and long-lasting antagonists of
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