C8604
Anti-CCR-5, N-Terminal antibody produced in rabbit
1 mg/mL, IgG fraction of antiserum, buffered aqueous solution
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.
General description
CCR5 is a chemokine receptor belonging to the super family of seven-transmembrane G-protein coupled receptors that mediates cellular functions of immune response, leukocyte migration, development and angiogenesis. CCR5 is expressed on macrophages and Th1 cells activated on inflammation, osteoclasts and vascular smooth muscle cells. Three CC chemokines, CCL3, 4 and 5 bind efficiently to CCR5, whereas CCL7, 8 and 13 bind less efficiently. The expression of CCR5 protein is most important in resistance to HIV-1 and hepatitis C virus infections and reportedly influences the course and progression of the infection. Anti-CCR5, N-Terminal specifically recognizes N terminal of human CCR5 (C-C chemokine receptor type 5).
Immunogen
synthetic peptide corresponding to the N-terminal amino acids 6-20 of human CCR5.
Application
Anti-CCR5, N-Terminal antibody may be used for western blot at 1 μg/mL and for immunohistochemistry at 2.5 μg/mL.
Physical form
Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Chemokine receptors: keys to AIDS pathogenesis?
D R Littman
Cell, 93(5), 677-680 (1998-06-18)
How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
D S Dimitrov
Cell, 91(6), 721-730 (1997-12-31)
Martin Coenen et al.
European journal of medical research, 15(3), 97-101 (2010-05-11)
Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes. The CCR5 chemokine receptor is expressed
Ghalib Alkhatib
Current opinion in HIV and AIDS, 4(2), 96-103 (2009-04-03)
We discuss the current knowledge concerning the biology of CXCR4 and CCR5 and their roles in HIV-1 infection. Important research findings reported in the last 2 years have advanced our knowledge in the field of HIV coreceptors and pathogenesis. Novel
K L Jones et al.
British journal of pharmacology, 162(7), 1453-1469 (2010-12-08)
There is increasing recognition of an important contribution of chemokines and their receptors in the pathology of atherosclerosis and related cardiovascular disease. The chemokine receptor CCR5 was initially known for its role as a co-receptor for HIV infection of macrophages
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