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C1145

Sigma-Aldrich

Cholesterol–PEG 600

Synonym(s):

Cholesterol, water soluble from sheep, Cholesteryl-polyethylene glycol 600 sebacate, Polyethylene glycol 600 mono(cholesteryl) ether sebacate, Polyoxyethyl-cholesteryl sebacate

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About This Item

CAS Number:
69068-97-9
MDL number:
MFCD00151772
UNSPSC Code:
41141804
eCl@ss:
39023139
NACRES:
NA.77

form

solid

extent of labeling

≥20% cholesterol

color

light yellow

solubility

H2O: 60 mg/mL

shipped in

dry ice

storage temp.

−20°C

General description

Cholesterol is one of the important constituent of all membranes. It is made up of a hydrophobic, planar, a polar hydroxyl group, fused-ring nucleus and a short hydrocarbon tail.

Application

Cholesterol-PEG 600 has been used to evaluate its ability to induce apoptosis in vascular smooth muscle cells. It has also been used to restore cholesterol following depletion by methyl β-cyclodextrin.

Biochem/physiol Actions

Cholesterol acts as an antecedent of steroid hormones. It plays a key role in fetal growth and in brain development.

Physical form

semisolid to solid

Preparation Note

Prepared by method of Proksch, G.J., and Bonderman, D.P., Clin. Chem., 24, 1924 (1978).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Lipids of Biological Membranes
The Membranes of Cells null
Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo
Yin J, et al.
Atherosclerosis, 148(2), 365-374 (2000)
M Absi et al.
British journal of pharmacology, 151(3), 332-340 (2007-04-24)
The small and intermediate conductance, Ca2+-sensitive K+ channels (SK(Ca) and IK(Ca), respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated. The effect of
Linda Shaw et al.
Cardiovascular research, 69(4), 825-835 (2006-02-09)
A close association of caveolae and sarcoplasmic reticulum (SR) has been suggested to be important for contractile activation of smooth muscle. Here, we investigate the presence of such arrangements in pressurised resistance arteries and examine the influence of two agents
Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin-rich domains
Absi M, et al.
British Journal of Pharmacology, 332-340, 332-340 null
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