FOXC2 belongs to the forkhead transcription factor family and has a distinct DNA-binding forkhead domain. Increased expression of FOXC2 is known to prevent hypertriglyceridemia and insulin resistance induced by diet. FOXC2 has also been implicated in the metastasis of breast cancer. Rabbit Anti-FOXC2 antibody recognizes human, mouse, and canine FOXC2.
Immunogen
Synthetic peptide directed towards the middle region of human FOXC2
Application
Rabbit Anti-FOXC2 can be used for western blot applications at a concentration of 1.25μg/ml.
Biochem/physiol Actions
FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.
Sequence
Synthetic peptide located within the following region: VIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAGSPDGSLPEHHA
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Proceedings of the National Academy of Sciences of the United States of America, 104(24), 10069-10074 (2007-06-01)
The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profiling, we have found that the FOXC2 transcription factor, which is involved in specifying mesenchymal
Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in adipocytes, has a pleiotropic effect
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