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A1709

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 1-10 human, rat

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C59H78N16O16S
CAS Number:
2791-05-1
Molecular Weight:
1299.41
MDL number:
MFCD00133029
UNSPSC Code:
12352200
PubChem Substance ID:
24890477

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189
P01194

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(O)=O)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(Cc3ccccc3)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NCC(O)=O

InChI

1S/C59H78N16O16S/c1-92-21-19-42(70-58(91)47(30-77)75-56(89)43(71-50(83)38(60)29-76)23-33-13-15-36(78)16-14-33)54(87)69-41(17-18-48(79)80)53(86)74-46(25-35-27-63-31-67-35)57(90)72-44(22-32-8-3-2-4-9-32)55(88)68-40(12-7-20-64-59(61)62)52(85)73-45(51(84)66-28-49(81)82)24-34-26-65-39-11-6-5-10-37(34)39/h2-6,8-11,13-16,26-27,31,38,40-47,65,76-78H,7,12,17-25,28-30,60H2,1H3,(H,63,67)(H,66,84)(H,68,88)(H,69,87)(H,70,91)(H,71,83)(H,72,90)(H,73,85)(H,74,86)(H,75,89)(H,79,80)(H,81,82)(H4,61,62,64)

InChI key

DIBOMWBTHPDGOJ-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Pomc(24664)

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly

Application

Adrenocorticotropic Hormone Fragment 1-10 [ACTH(1-10)] is used as a model peptide to study the the suitability of various mimic structures to make micelle models of biological membranes.

Biochem/physiol Actions

Facilitates avoidance acquisition. Lacks adrenocorticotropic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Tuck C Wong et al.
Journal of biomolecular structure & dynamics, 20(1), 39-57 (2002-07-30)
The structure and interactions of the 1-24 fragment of the adrenocorticotropin hormone, ACTH (1-24), with membrane have been studied by molecular dynamics (MD) simulation in an NPT ensembles in two explicit membrane mimics, a dodecylphosphocholine (DPC) micelle and a dimyristoylphosphatidylcholine
T Wymore et al.
Journal of biomolecular structure & dynamics, 18(3), 461-476 (2001-01-10)
ACTH (1-10), an adrenocorticotropin hormone fragment, was studied by molecular dynamics (MD) simulation in the NPT ensemble in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements were incorporated during the equilibration stage of
M D Gomar et al.
Experientia, 51(3), 209-212 (1995-03-15)
In this study, we examined the effect of intracerebroventricular (i.c.v) injection of melatonin and/or ACTH1-10 and ACTH4-10 on [3H]flunitrazepam binding sites in the cerebral cortex of hypophysectomized rats. Hypophysectomy increased the Bmax (maximum number of binding sites) of benzodiazepine (BNZ)
Molecular dynamics simulation of adrenocorticotropin (1-10) peptide in a solvated dodecylphosphocholine micelle.
Gao X, Wong TC.
Biopolymers, 58, 6430659-6430659 (2001)
M J Hoogduijn et al.
Biochemical and biophysical research communications, 290(2), 844-850 (2002-01-12)
The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin receptors have been identified, of which the melanocortin 5 receptor (MC5R) has the most widespread

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