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58756

Sigma-Aldrich

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine

≥98.0% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7

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5 MG
$194.00

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$194.00

About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
84477-73-6
Molecular Weight:
291.37
Beilstein:
5445506
MDL number:
MFCD00132900
UNSPSC Code:
12352202
PubChem Substance ID:
57651659
NACRES:
NA.77

$194.00

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Assay

≥98.0% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3

InChI key

QGSCXAWTTISKLF-UHFFFAOYSA-N

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Biochem/physiol Actions

Less potent inhibitor of protein kinaseC than H-7

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J Duraj et al.
Neoplasma, 44(4), 205-211 (1997-01-01)
The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45R0. Immunoprecipitation revealed two antigen specificities on
C C Chua et al.
Biochimica et biophysica acta, 1401(2), 187-194 (1998-04-09)
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and a vascular permeability factor. In this study we found that the addition of angiotensin II (AII) to rat heart endothelial cells induced VEGF mRNA production. VEGF mRNA
C D Balaban et al.
Brain research, 845(1), 97-101 (1999-10-26)
This study tests the hypothesis that activation of protein kinase C (PKC) is a critical step for early recovery from spontaneous nystagmus after unilateral ablation of the vestibular periphery. Halothane-NO(2)-O(2)-anesthetized Long-Evans rats received a 5-microl intracerebroventricular bolus of vehicle (distilled
C A Gebert et al.
Molecular endocrinology (Baltimore, Md.), 13(1), 38-56 (1999-01-19)
STAT5b (signal transducer and activator of transcription 5b) is a key mediator of the effects of plasma GH pulses on male-specific liver gene expression. STAT5b is activated in liver cells in vivo by physiological pulses of GH and then is
H Takahashi et al.
Biological & pharmaceutical bulletin, 20(4), 446-448 (1997-04-01)
Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal membrane resistance (Rm)
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