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Sigma-Aldrich

Tetramethylrhodamine isothiocyanate–Dextran

average mol wt 40,000

Synonym(s):

TRITC-Dextran 40, TRITC-Dextran

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About This Item

MDL number:
MFCD00132418
UNSPSC Code:
12352116
NACRES:
NA.32

biological source

synthetic

form

powder

mol wt

average mol wt 40,000

extent of labeling

0.001-0.008 mol/mol TRITC glucose

fluorescence

λex 550 nm; λem 577 nm±5 nm in 0.1 M Tris pH 8.0

application(s)

cell analysis

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General description

Tetramethylrhodamine isothiocyanate–Dextran, also known as TRITC-Dextran or TRITC-Dextran 40, is a fluorescent dye and a novel drug. The fluorescent activity of TRITC-Dextran is detected at 555nm wavelength. The TRITC-Dextran molecules are released in the cells through passive diffusion due to a concentration gradient.

Application

Tetramethylrhodamine isothiocyanate–Dextran (TRITC-Dextran 40) is used as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular drug delivery.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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J David Symons et al.
Arteriosclerosis, thrombosis, and vascular biology, 22(5), 772-780 (2002-05-15)
High circulating concentrations of homocysteine (ie, hyperhomocysteinemia [Hhcy]) impair the vascular function of peripheral conduit arteries and arterioles perfusing splanchnic and skeletal muscle regions. The effects of HHcy on coronary resistance vessel function and other indexes of vascular function, ie
Weijun Tong et al.
The journal of physical chemistry. B, 109(27), 13159-13165 (2006-07-21)
Multilayer microcapsules showing unique charge-controlled permeability have been successfully fabricated by employing poly(styrene sulfonate) (PSS)-doped CaCO3 particles as templates. Encapsulation of the PSS molecules is thus achieved after core removal. Scanning force microscopy (SFM), UV-vis, Raman spectroscopy, and zeta-potential confirm
Andrea Kassner et al.
Neuroimaging clinics of North America, 21(2), 315-325 (2011-06-07)
The blood-brain barrier (BBB) is a functional concept to describe unique features of intracranial blood vessels that prevent many substances in the systemic circulation from entering the brain. In the setting of acute ischemic stroke, loss of blood-brain barrier (BBB)
Shuning Bian et al.
The Review of scientific instruments, 88(3), 034302-034302 (2017-04-05)
The development of a multimodal instrument capable of real-time in situ measurements of cavitation activity and effect in tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments is described here. The instrument features an acoustic arm that can
Kimberley J Reeves et al.
Journal of vascular research, 49(2), 132-143 (2012-01-21)
This study evaluated four fluorescent-protein conjugates to monitor microcirculatory variables using the murine cremaster muscle and determined acute and long-term responses to repeated administration of FITC-BSA [conjugated at the University of Sheffield (UoS)] within a dorsal microcirculatory chamber (DMC) in
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