RTC000076

Methanol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Methanol, Methyl alcohol
• Linear Formula: CH₃OH
• CAS Number: 67-56-1
• Molecular Weight: 32.04
• Beilstein: 1098229
• MDL number: MFCD00004595
• UNSPSC Code: 41116107
• NACRES: NA.05

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1424109
• vapor density: 1.11 (vs air)
• vapor pressure: 410 mmHg ( 50 °C); 97.68 mmHg ( 20 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 725 °F
• expl. lim.: 36 %
• packaging: pkg of 20 mL
• refractive index: n20/D 1.329 (lit.)
• bp: 64.7 °C (lit.)
• mp: −98 °C (lit.)
• density: 0.791 g/mL at 25 °C (lit.)
• application(s): pharmaceutical small molecule
• format: neat
• storage temp.: 2-30°C
• SMILES string: CO
• InChI: 1S/CH4O/c1-2/h2H,1H3
• InChI key: OKKJLVBELUTLKV-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

<ul>
<li><strong>HPLC-HESI-MS/MS Analysis of Phenolic Compounds from Cynoglossum tubiflorus Leaf Extracts:</strong> This study demonstrates the utilization of high-purity methanol as a solvent in the extraction and analysis of phenolic compounds, showcasing its role in identifying cytotoxic, antioxidant, and antibacterial properties. It also shows effectiveness in reducing Fe³⁺;to Fe²⁺, converting Mo⁶⁺;to Mo⁵⁺, and scavenging free radicals.(Dallali et al., 2024).</li>
<li><strong>Therapeutic Drug Monitoring Using RP-HPLC-PDA:</strong> Methanol is employed ;as a mobile phase in a reversed-phase high-performance liquid chromatography with photodiode array detection for the monitoring of multiple drugs.; (Hesham et al., 2024).</li>
<li><strong>Chiral Resolution of Cationic Piperazine Derivatives:</strong> Methanol is used in capillary electrophoresis for the chiral resolution of pharmaceutical compounds, demonstrating its utility in ensuring the purity and efficacy of chiral drugs. (Niaei et al., 2024).</li>
<li><strong>Determination of Chemical Components in Endemic Plant Species:</strong> Utilizes methanol in liquid chromatography-mass spectrometry to identify and quantify the bioactive compounds in Allium turcicum, showcasing methanol′s role in extracting and analyzing plant metabolites for medicinal potential assessments (Ipek et al., 2024).</li>
<li><strong>Comprehensive Analysis of Carotenoids in Microalgae:</strong> This research uses methanol for the extraction and quantification of lutein and loroxanthin from Scenedesmus obliquus. Methanol′s effectiveness in extracting sensitive compounds underlines its importance in nutritional and biochemical research (Erdogan et al., 2024).</li>
</ul>

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB9768 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F
• Flash Point(C): 9.7 °C