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Key Documents

B1385

Supelco

Butoxamine hydrochloride

analytical standard, for drug analysis, mixture of diastereomers

Synonym(s):

α-(1-[t-Butylamino]ethyl)-2,5-dimethoxybenzyl alcohol

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About This Item

Empirical Formula (Hill Notation):
C15H25NO3 · HCl
CAS Number:
Molecular Weight:
303.82
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)C(C)NC(C)(C)C

InChI

1S/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H

InChI key

URPAECSKKQLCII-UHFFFAOYSA-N

General description

Butoxamine hydrochloride is a β-andrenoceptor antagonist, which shows β2-selectivity.[1][2]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Claudio Molinari et al.
Endocrinology, 148(8), 4080-4090 (2007-04-28)
Prolactin has been associated with many effects and has been implicated in the pathogenesis of pregnancy-related hypertensive disorders, although little is known about its vascular effects. The present study was designed to determine the primary effect of prolactin on regional
Nozomu Abe et al.
BioMed research international, 2020, 3214186-3214186 (2020-05-29)
Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate the involvement of α-adrenergic receptors in the process of exocytosis. Since exocytosis in mast cells can be detected electrophysiologically by the
Dong Zhang et al.
Pancreas, 38(1), 94-100 (2008-12-25)
Propranolol inhibited pancreatic cancer cell proliferation by blocking signaling through the beta-adrenoceptor. We hypothesized that propranolol may suppress pancreatic cancer cell growth through induction of apoptosis. The beta-adrenoceptor antagonist propranolol, beta1-adrenoceptor antagonist metoprolol, and beta2-adrenoceptor antagonist butoxamine were used to
Jiayin Lu et al.
International journal of molecular sciences, 22(3) (2021-02-06)
Restraint stress causes various maternal diseases during pregnancy. β2-Adrenergic receptor (β2-AR) and Forkhead transcription factor class O 1 (FOXO1) are critical factors not only in stress, but also in reproduction. However, the role of FOXO1 in restraint stress, causing changes
Jiayin Lu et al.
Stress (Amsterdam, Netherlands), 24(5), 514-528 (2020-12-08)
During pregnancy, uterus undergoes the environment adaptation as part of a program of development. In the world, one in four people worldwide suffer from mental illness, especially pregnant women. β-Adrenergic receptor (β-AR) is an important regulator that converts environmental stimuli

Questions

  1. Can B1385 be used in mice?

    1 answer
    1. This product has not been tested for in vitro or in vivo use and is intended to be used as an analytical standard. While the material is not suitable for human or veterinary use, other researchers have used this item successfully in mouse models. See the link below to review a publication that may be of interest:
      https://pmc.ncbi.nlm.nih.gov/articles/PMC7867244/

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