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PI-12K

Sigma-Aldrich

Porcine Insulin RIA

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

grade

for protein analysis

Quality Level

100

description

ED<sub>80</sub> = 7 ± 0.6 µU/ml ED<sub>50</sub> = 30 ± 1.2 µU/ml ED<sub>20</sub> = 126 ± 3.0 µU/ml
analytes available: Insulin
 2-200 pg/mL (standard curve range)

species reactivity

pig

technique(s)

radioimmunoassay: suitable

UniProt accession no.

P01308P01315

detection method

radioactive

General description

FUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SIZE: 110 amino acids; 11981 Da
SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.

Specificity

Porcine Insulin 100% Procine Proinsulin 53% Human Insulin 100% Bovine Insulin 90% Bovine Proinsulin 50% Intact Human Proinsulin 38% Rat Insulin 19% Des 31, 32 HPI 47% Des 64, 65 HPI 72% Glucagon Not Detectable Pancreatic Polypeptide Not Detectable Somatos

Application

Overnight, equilibrium incubation at 4°C. Sample volume ≤ 100 μl serum, plasma, or tissue culture media.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

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