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ABC490

Sigma-Aldrich

Anti-BCL2A1/BFL-1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

BCL2A1/BFL-1, Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

bat (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), Camelidae (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001108207

UniProt accession no.

Q16548

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BCL2A1(597)

General description

Bcl-2-related protein A1 (BCL2A1), also known as protein BFL-1, protein GRS, and Bcl-2-like protein 5 (Bcl2-L-5), is a member of the Bcl-2 family. BCL2A1/BFL-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. BCL2A1/BFL-1 expression is reported in peripheral blood, spleen, bone marrow, lung, small intestine, and testis.

Immunogen

KLH-conjugated linear peptide corresponding to the near N-terminal of human BCL2A1/BFL-1.

Application

Anti-BCL2A1/BFL-1 Antibody is an antibody against BCL2A1/BFL-1 for use in Western Blotting and Immunohistochemistry.
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected BCL2A1/BFL-1 in human breast cancer and human bone marrow tissue.

Quality

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected BCL2A1/BFL-1 in 10 µg of human spleen tissue lysate.

Target description

~18 kDa observed

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Warren Fiskus et al.
Blood cancer journal, 12(1), 5-5 (2022-01-13)
Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressing mutant (mt)-NPM1. Following MI treatment, although

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