8.51056

HOSu

Novabiochem^®

• Synonym(s): HOSu, 1-Hydroxy-2,5-pyrrolidinedione, N-Hydroxysuccinimide, NHS
• Empirical Formula (Hill Notation): C₄H₅NO₃
• CAS Number: 6066-82-6
• Molecular Weight: 115.09
• MDL number: MFCD00005516
• UNSPSC Code: 12352005
• EC Index Number: 228-001-3
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥99.0% (acidimetric)
• form: powder
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• pH: 5-7 (20 °C, 50 g/L in H₂O)
• mp: 93-100 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• InChI: 1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
• InChI key: NQTADLQHYWFPDB-UHFFFAOYSA-N

Description

General description

Reagent used for the synthesis of water-soluble active esters and as an additive to suppress enantiomerization during carbodiimide condensations ^[1,2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] G. W. Anderson, et al. (1964) J. Am. Chem. Soc., 86, 1839.
^[2] F. Weygand, et al. (1966) Z. Naturforsch., 21, 426.

Linkage

Replaces: 01-62-0009

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Solubility (1 mmole in 2 ml DMF): clearly soluble
Identity (IR): passes test

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H315 - H318
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable