The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
SIRT1 Inhibitor III, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
Biochem/physiol Actions
Primary Target SIRT1
Target IC50: 98 nM against SIRT1
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Solomon, J.M., et al. 2006. Mol. Cell. Biol.26, 28. Napper, A.D., et al. 2005. J. Med. Chem.48, 8045.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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