557353

RORγ Inverse Agonist, SR2211

The RORγ Inverse Agonist, SR2211 controls the biological activity of RORγ.

• Synonym(s): RORγ Inverse Agonist, SR2211, 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4′-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
• Empirical Formula (Hill Notation): C₂₆H₂₄F₇N₃O
• CAS Number: 1359164-11-6
• Molecular Weight: 527.48
• MDL number: MFCD25563263
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: FC1=CC(C(O)(C(F)(F)F)C(F)(F)F)=CC=C1C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2

Description

General description

A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (K_i = 105 nM; IC₅₀ ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kumar, N., et al. 2012. ACS Chem. Biol.7, 672.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable