5.05278

PNU 282987

• Synonym(s): PNU 282987, PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
• Empirical Formula (Hill Notation): C₁₄H₁₇ClN₂O · xHCl
• CAS Number: 123464-89-1
• Molecular Weight: 264.75 (free base basis)
• UNSPSC Code: 12352200

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 26 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1
• InChI key: HSEQUIRZHDYOIX-ZOWNYOTGSA-N

Description

General description

A potent agonist highly selective for α7 nAChRs (K_i = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Biochem/physiol Actions

Primary Target
α7 nAChRs

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hajós, M., et al., 2010, Curr. Pharm. Des.16, 538.
Bodnar, L., et al., 2005. J. Med. Chem.48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther.312, 1213.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3