344281-M

Forskolin, NKH477

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

• Synonym(s): Forskolin, NKH477, 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
• Empirical Formula (Hill Notation): C₂₇H₄₃NO₈ · xHCl
• CAS Number: 138605-00-2
• Molecular Weight: 509.63 (free base basis)
• MDL number: MFCD00236421
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 10 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
• InChI key: VIRRLEDAYYYTOD-YHEOSNBFSA-N

Description

General description

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

Warning

Toxicity: Highly Toxic (H)

Other Notes

Nakashima, S., et al. 2005. J. Heart Lung Transplant.24, 462.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable