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1370327

USP

Lorazepam Related Compound A

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

3-(Acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, (±)-Lorazepam

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About This Item

Empirical Formula (Hill Notation):
C17H12Cl2N2O3
CAS Number:
Molecular Weight:
363.19
Beilstein:
764089
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

lorazepam

manufacturer/tradename

USP

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O

InChI

1S/C17H12Cl2N2O3/c1-9(22)24-17-16(23)20-14-7-6-10(18)8-12(14)15(21-17)11-4-2-3-5-13(11)19/h2-8,17H,1H3,(H,20,23)

InChI key

CYDZMDOLVUBPNL-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lorazepam Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Lorazepam
  • Lorazepam Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Recurrent complex partial status epilepticus associated with tiagabine rechallenge.
R Brouns et al.
Acta neurologica Belgica, 102(1), 19-20 (2002-07-04)
Application of ultrafiltration and CD spectroscopy for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 109(3), 851-857 (1982-12-15)
Stationary ultrafiltration: a radio-tracer technique for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 97(1), 1-7 (1980-11-17)
Ilona Fitos et al.
Chirality, 14(5), 442-448 (2002-05-02)
Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Binding kinetics were followed by recording changes in the fluorescence of warfarin
I Fitos et al.
Chirality, 11(2), 115-120 (1999-02-10)
The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)-(S)-ibuprofen. The phenomenon is an

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