TRUERGD
TrueGel3D RGD
Integrin Adhesion Peptide
Synonym(s):
3D cell culture matrix
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About This Item
UNSPSC Code:
12352207
NACRES:
NA.71
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shipped in
dry ice
storage temp.
−20°C
General description
RGD sequences on extracellular matrix proteins (fibronectin, vitronectin) promote cell adhesion to cellular integrin receptors. The thiol group on the N-terminus of TrueGel3D® RGD peptide acts as linker to bind RGD motif to the polymer (Dextran/PVA). The conjugated RGD motif on polymer promotes adhesion of cells with appropriate integrin receptors.
TrueGel3D® is a commercially available polymer-based diverse array of scaffolds for 3D in vitro tumor models. The RGD peptide present in these hydrogels enable cell attachment.
Application
Polymer with cell adhesion motif (RGD) employed to generate cell-adhesive hydrogel
Features and Benefits
Contains cell adhesion motif RGD (Acetyl-Cys-Doa*-Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2), which binds to appropriate integrin receptors on cells.
*Doa : 8-amino-3,6-dioxaoctanoic acid
*Doa : 8-amino-3,6-dioxaoctanoic acid
Components
TRUERGD contains RGD degradable polymer lyophilized and water
Legal Information
TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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Steven R Caliari et al.
Nature methods, 13(5), 405-414 (2016-04-29)
There is growing appreciation of the role that the extracellular environment plays in regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in concert, can drastically alter cell function. Biomaterials, and particularly hydrogels, have been developed and implemented
L P Ferreira et al.
Acta biomaterialia, 75, 11-34 (2018-05-29)
Three-dimensional multicellular tumor models are receiving an ever-growing focus as preclinical drug-screening platforms due to their potential to recapitulate major physiological features of human tumors in vitro. In line with this momentum, the technologies for assembly of 3D microtumors are
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