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Key Documents

SRP6309

Sigma-Aldrich

Proteinase 3 from human neutrophils

≥95% (SDS-PAGE)

Synonym(s):

AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen

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About This Item

UNSPSC Code:
12352200

biological source

human

Assay

≥95% (SDS-PAGE)

form

frozen liquid

mol wt

29 kDa

packaging

pkg of 25 μg

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... AGP7(5657)

General description

Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by α1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation. Proteinase 3 (PR-3) is also known as myeloblastin and p29b.

Physical form

Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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