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SML3795

Sigma-Aldrich

BAY-3827

≥98% (HPLC)

Synonym(s):

AMPK inhibitor BAY3827, BAY 3827, N-[5-(3,5-Dicyano-1,2,6-trimethyl-1,4-dihydropyridin-4-yl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide, N-[5-(3,5-Dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethylbenzamide

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About This Item

Empirical Formula (Hill Notation):
C27H25FN6O
CAS Number:
2377576-35-5
Molecular Weight:
468.53
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N#CC1=C(N(C(C)=C(C#N)C1C2=CC3=C(NN=C3NC(C4=C(C=CC=C4)CC)=O)C(C)=C2F)C)C

InChI key

OZFFKOSQNBBYCA-UHFFFAOYSA-N

Biochem/physiol Actions

BAY-3827 is a selective and potent inhibitor of AMPK (AMP-activated protein kinase) and RSK1 (ribosomal 6 kinase 1) that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines. BAY-3827 strongly down-regulates lipase E (LIPE), cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B), serine-threonine kinase AKT3 and carnitine palmitoyl-transferase 1 (CPT1) family expression levels and impairs lipid flux.
Selective and potent inhibitor of AMPK and RSK1 that exhibit strong anti-proliferative activity in androgen-dependent prostate cancer cell lines

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000392827
0000392827
0000264771
0000264772
0000253933

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Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle
Developmental Cell, 58(4), 289-305 (2023)
Anti-Na+/K+-ATPase DR antibody attenuates UUO-induced renal fibrosis through inhibition of Na+/K+-ATPase ?1-dependent HMGB1 release
Zheng J, Lan P, Li M, Kang MC, Xun M, Ma X, Yan M, Sun D, Shen Y, Fu X, Ding X, Yan X, Xue WJ
International Immunopharmacology, 116, 109826-109826 (2023)
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Cellular oncology, 44(3), 581-594 (2021)

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