SML0552

Tirapazamine

≥98% (HPLC)

• Synonym(s): 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine, SR 259075, SR 4233, Tirazone, Win 59075
• Empirical Formula (Hill Notation): C₇H₆N₄O₂
• CAS Number: 27314-97-2
• Molecular Weight: 178.15
• MDL number: MFCD00132954
• UNSPSC Code: 12352116
• PubChem Substance ID: 329825548
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , orange to dark orange-red
• solubility: DMSO: 10 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Nc1n[n+]([O-])c2ccccc2[n+]1[O-]
• InChI: 1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
• InChI key: ORYDPOVDJJZGHQ-UHFFFAOYSA-N

Description

Application

Tirapazamine has been used to evaluate its cytotoxic effect on U-251 MG (glioblastoma cell line) cell viability.

Biochem/physiol Actions

Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable