SML0505

Tienilic Acid

≥98% (HPLC)

• Synonym(s): Ticrynafen, Tienylic acid, [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid
• Empirical Formula (Hill Notation): C₁₃H₈Cl₂O₄S
• CAS Number: 40180-04-9
• Molecular Weight: 331.17
• EC Number: 254-826-3
• MDL number: MFCD00867339
• UNSPSC Code: 12161501
• PubChem Substance ID: 329825452
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(=O)COc1ccc(c(Cl)c1Cl)C(=O)c2cccs2
• InChI: 1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
• InChI key: AGHANLSBXUWXTB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable