PZ0142

PD-180970

≥98% (HPLC)

• Synonym(s): 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one, PF-1515965
• Empirical Formula (Hill Notation): C₂₁H₁₅Cl₂FN₄O
• CAS Number: 287204-45-9
• Molecular Weight: 429.27
• MDL number: MFCD10565929
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823727
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• color: yellow
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)C(=Cc2cnc(Nc3ccc(F)c(C)c3)nc12)c4c(Cl)cccc4Cl
• InChI: 1S/C21H15Cl2FN4O/c1-11-8-13(6-7-17(11)24)26-21-25-10-12-9-14(20(29)28(2)19(12)27-21)18-15(22)4-3-5-16(18)23/h3-10H,1-2H3,(H,25,26,27)
• InChI key: SLCFEJAMCRLYRG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PD-180970 is a potent inhibitor of the p210 Bcr-Abl tyrosine kinase.

Features and Benefits

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Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H413
• Precautionary Statements: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable