P3418
Poly-(α,β)-DL-aspartic acid sodium salt
mol wt 2,000-11,000
Synonym(s):
Aspartic acid homopolymer sodium salt
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Application
- Improving the effectiveness of (-)-epigallocatechin gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and polyaspartic acid.: This research highlights the development of nanoparticles using polyaspartic acid to enhance the bioavailability and therapeutic effect of EGCG in treating atherosclerosis (Hong et al., 2014).
- Polyaspartate, a biodegradable chelant that improves the phytoremediation potential of poplar in a highly metal-contaminated agricultural soil.: The study evaluates the use of polyaspartate in enhancing the phytoremediation capabilities of poplar trees, showcasing its environmental application for soil decontamination (Lingua et al., 2014).
- Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning.: This research investigates the role of polyaspartate in modulating the growth of calcium oxalate crystals, with implications for understanding kidney stone formation (Chien et al., 2009).
Preparation Note
Prepared by thermal polycondensation.
Analysis Note
Molecular weight based on viscosity.
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Kovacs, J.
The Journal of Organic Chemistry, 26, 1084-1084 (1961)
Fabio Nudelman et al.
Nanoscale, 2(11), 2436-2439 (2010-09-14)
Amorphous calcium carbonate (ACC) nanoparticles of different size are prepared using a flow system. Post-synthesis stabilization with a layer of poly[(α,β)-dl-aspartic acid] leads to stabilization of the ACC, but only for particles <100 nm. Larger and uncoated particles readily convert
Lin Gui et al.
Nanomedicine (London, England), 5(5), 703-714 (2010-07-29)
Applying nanoscale assembly to the design of a thrombolytic agent. poly-alpha,beta-DL-aspartyl-L-alanine (molecular weight: 15726 atomic mass units) from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-alanine. The correlation of concentration and pH with nanofeatures, the
Yangzhi Guping et al.
Drug delivery, 12(2), 89-96 (2005-04-15)
A new class of biodegradable poly-amino acid, alpha,beta-poly[(N-hydroxypropyl/aminoethyl)-DL-Aspartamide-co-L-Lysine] (PHAAL), was synthesized by ring-opening of poly[succinimide-co-lysine](PSL) with n-propanolamine and ethylene diamine after thermal copolycondensation of DL-Aspartic acid and L-lysine under reduced pressure. Different ratio feeds of PSL were obtained and characterized
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