P1584
Peptidyl Arginine Deiminase from rabbit skeletal muscle
buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)
Synonym(s):
Protein arginine iminohydrolase
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
form
buffered aqueous glycerol solution
Quality Level
specific activity
≥200 units/mg protein (Bradford)
relevant disease(s)
arthritis (rheumatoid )
shipped in
dry ice
storage temp.
−70°C
Looking for similar products? Visit Product Comparison Guide
General description
Peptidyl arginine deiminase is the enzyme that converts arginine into citrulline.
Application
Peptidyl arginine deiminase has been used in a study that assessed promising novel biomarkers for the early diagnosis of rheumatoid arthritis. It has also been used in a study to investigate the autopathogenic correlation of periodontitis and rheumatoid arthritis.
Biochem/physiol Actions
Calcium is required for peptidylarginine deiminase activity in vitro.
Unit Definition
One unit will produce 1 μmole of N-α-benzoylcitrulline ethyl ester from BAEE per hr at 55 °C at pH 7.2.
Physical form
Solution in 20 mM Tris-HCl, pH 7.4, containing 10 mM 2-mercaptoethanol, 1 mM EDTA and 10% glycerol
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Leendert A Trouw et al.
Autoimmunity reviews, 12(2), 318-322 (2012-06-06)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints affecting about 0.5% of the general population. Early treatment in RA is important as it can prevent disease progression and irreversible damage of the
John G Routsias et al.
Rheumatology (Oxford, England), 50(7), 1189-1193 (2011-02-24)
Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa. Both diseases are characterized by chronic inflammation, osseous destruction, damage of the supporting soft tissues, similar cellular immune responses and common
Murat Bozdag et al.
Bioorganic & medicinal chemistry letters, 23(3), 715-719 (2012-12-26)
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non
Joyce J B C van Beers et al.
Biochimie, 95(2), 299-308 (2012-10-03)
Citrullination, the conversion of peptidylarginine to peptidylcitrulline is catalyzed by peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation among different tissues as demonstrated by PAD mRNA analyses. Here we have analyzed the differential expression of PAD2, PAD4
Isabelle Auger et al.
Arthritis and rheumatism, 62(1), 126-131 (2009-12-30)
Autoantibodies to citrullinated proteins are specific for rheumatoid arthritis (RA) and recognize epitopes centered by citrulline, a posttranslationally modified form of arginine. Peptidyl arginine deiminase type 4 (PAD-4), the enzyme that converts arginine into citrulline, is in itself a target
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service