M9808
Anti-Muscarinic Acetylcholine Receptor (M1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Acetylcholine Receptor antibody
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, rat
technique(s)
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CHRM1(1128)
rat ... Chrm1(25229)
General description
Muscarinic acetylcholine receptor 1 (M1) is a member of class A G protein-coupled receptors (GPCRs) family, which is encoded by the CHRM1 gene. Muscarinic receptors have seven transmembrane domains localized in the parasympathetic nerve sub-synaptic membrane. The CHRM1 gene is located on human chromosome location 11q12.3.
Muscarinic cholinergic receptor 1 (M1) is seen in the forebrain of rats.
Immunogen
GST fusion protein of a part of the i3 intracellular loop of human M1 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-353.1, 2
Application
Anti-Muscarinic acetylcholine receptor (M1) antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Muscarinic acetylcholine receptor 1 (M1) regulates normal prostate growth and reduced-level glandular secretion. Muscarinic receptors play a major role in tumor progression. Muscarinic acetylcholine receptors (mAChRs) regulates adenylyl cyclase and potassium channel activities. It also stimulates various mitogen-activated protein kinases. M1 may be useful for the discovery of therapeutics for Alzheimer′s disease.
Studies have shown that activation of muscarinic cholinergic receptor 1 (M1) in rats leads to changes in the endotoxin tolerance in the liver.
Physical form
Lyophilized from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling
Yin QQ, et al.
Asian Journal of Andrology, 20(6), 608-608 (2018)
The relationship between plasma levels of clozapine and n-desmethyclozapine as well as m1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia
Kir Y, et al.
Psychiatry research. Neuroimaging, 111128-111128 (2020)
Tamara Stojanovic et al.
Cells, 11(2) (2022-01-22)
Nicotine addiction develops predominantly during human adolescence through smoking. Self-administration experiments in rodents verify this biological preponderance to adolescence, suggesting evolutionary-conserved and age-defined mechanisms which influence the susceptibility to nicotine addiction. The hippocampus, a brain region linked to drug-related memory
Golnar Eftekhari et al.
European journal of pharmacology, 740, 436-441 (2014-07-11)
Endotoxin tolerance is a mechanism in which cells receiving low doses of endotoxin, enter a transient phase with less inflammatory response to the next endotoxin challenges. Central nervous system is known to modulate systemic inflammation through activation of the cholinergic
Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
Abdul-Ridha A, et al.
Test, 289(48) (2014)
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