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82435

Sigma-Aldrich

Puerarin

≥98.0% (HPLC)

Synonym(s):

8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kakonein

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About This Item

Empirical Formula (Hill Notation):
C21H20O9
CAS Number:
3681-99-0
Molecular Weight:
416.38
Beilstein:
64198
MDL number:
MFCD00076007
UNSPSC Code:
12352200
PubChem Substance ID:
57652917
NACRES:
NA.77

Quality Level

100

Assay

≥98.0% (HPLC)

form

powder

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)ccc3C(=O)C(=COc23)c4ccc(O)cc4

InChI

1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

InChI key

HKEAFJYKMMKDOR-VPRICQMDSA-N

Gene Information

mouse ... Aldh1a2(19378) , Maoa(17161)

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Biochem/physiol Actions

Isoflavone component of kudzu. Reduces anxiety symptoms associated with alcohol withdrawal.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David H Overstreet et al.
Pharmacology, biochemistry, and behavior, 75(3), 619-625 (2003-08-05)
Because extracts of kudzu have been used as a hangover remedy in China for many centuries, we tested the ability of NPI-031G (puerarin), an isoflavone isolated from kudzu, to counteract anxiogenic effects associated with withdrawal from chronic alcohol exposure. NPI-O31G
Rong Li et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 69-75 (2012-11-14)
This study was designed to evaluate the potential effects of puerarin (PR), an effective isoflavonoid compound purified from Pueraria lobata, in treating hepatic fibrosis (HF) rats induced by carbon tetrachloride (CCl(4), 2 mL kg(-1) d(-1)). Compared to model control, PR
E Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(1), 49-52 (2013-04-20)
To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets.
Li Jiang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 915-916, 8-12 (2013-01-15)
Gastrodin (Gas) and puerarin (Pur) are bioactive substances derived from traditional Chinese medicine Gastrodia elata and Radix Puerariae, respectively, which were often used together in Chinese clinical prescriptions. Their injections were used in combined way for treatment of some cardiocerebrovascular
Feng Tian et al.
Neuroscience letters, 543, 64-68 (2013-04-11)
Puerarin extracted from radix puraeriae is shown to exert a variety of pharmacological effects including neuroprotective properties. However, its mechanisms of action are needed to further explore. The study was designed to investigate the mechanism of puerarin treatment of acute
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